Risk factors for recurrence after 5-year endocrine therapy in postoperative breast cancer patients / 中华普通外科杂志
Chinese Journal of General Surgery
; (12): 305-308, 2018.
Article
em Zh
| WPRIM
| ID: wpr-710539
Biblioteca responsável:
WPRO
ABSTRACT
Objective To evaluate recurrence risk factors in postoperative breast cancer patients after 5-year adjuvant endocrine therapy.Methods From Jan 2006 to Dec 2011,a total of 327 patients were enrolled for this study.Kaplan-Meier curves were applied to estimate survival rates and COX's proportional hazards model to identify prognostic variables.Results Among these 327 eligible patients,42 (12.8%) patients suffered from distant metastasis and 34 (10.4%) patients experienced locoregional recurrence after 5-year adjuvant endocrine therapy.Survival analysis showed that patients with histologic grade 3 disease,lymph node metastasis,Ki-67 high expression,high TNM stage and radiotherapy were statistically significant with poorer relapse-free survival (RFS,P =0.000,0.003,0.000,0.003,0.034)and poorer distant metastasis-free survival (DMFS,P =0.000,0.002,0.000,0.002,0.023),respectively.In multivariate analysis,patients with histological grade 3 disease (P =0.002) and more than 3 positive nodes (P =0.032) were risk factors for lower RFS.However,only histological grade 3 (P =0.015) was risk factor for DMFS.Conclusions Late relapse after completion of 5-year adjuvant endocrine therapy was still common,patients with grade 3 disease and more than 3 positive nodes may benefit from extended endocrine therapy.
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Índice:
WPRIM
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
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Risk_factors_studies
Idioma:
Zh
Revista:
Chinese Journal of General Surgery
Ano de publicação:
2018
Tipo de documento:
Article