The effect of near-infrared fluorescence conjugation on the anti-cancer potential of cetuximab / 한국실험동물학회지
Laboratory Animal Research
; : 30-36, 2018.
Article
em En
| WPRIM
| ID: wpr-713482
Biblioteca responsável:
WPRO
ABSTRACT
This study investigated the anti-cancer potential of a near-infrared fluorescence (NIRF) molecule conjugated with Cetuximab (Cetuximab-NIRF) in six-week-old female BALB/c athymic (nu+/nu+) nude mice. A431 cells were cultured and injected into the animals to induce solid tumors. Paclitaxel (30 mg/kg body weight (BW)), Cetuximab (1 mg/kg BW), and Cetuximab-NIRF (0.25, 0.5 and 1.0 mg/kg BW) were intraperitoneally injected twice a week into the A431 cell xenografts of the nude mice. Changes in BW, tumor volume and weight, fat and lean mass, and diameter of the peri-tumoral blood vessel were determined after two weeks. Tumor volumes and weights were significantly decreased in the Cetuximab-NIRF (1 mg/kg BW) group compared with the control group (P < 0.001). Lean mass and total body water content were also conspicuously reduced in the Cetuximab-NIRF (1 mg/kg BW) group compared with the vehicle control group. Peri-tumoral blood vessel diameters were very thin in the Cetuximab-NIRF groups compared with those of the paclitaxel group. These results indicate that the conjugation of Cetuximab with NIRF does not affect the anti-cancer potential of Cetuximab and NIRF can be used for molecular imaging in cancer treatments.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Pesos e Medidas
/
Vasos Sanguíneos
/
Água Corporal
/
Peso Corporal
/
Paclitaxel
/
Carga Tumoral
/
Imagem Molecular
/
Xenoenxertos
/
Fluorescência
/
Cetuximab
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Laboratory Animal Research
Ano de publicação:
2018
Tipo de documento:
Article