Long-term prenatal stress increases susceptibility of N-methyl-D-aspartic acid-induced spasms in infant rats / 소아과
Korean Journal of Pediatrics
; : 150-155, 2018.
Article
em En
| WPRIM
| ID: wpr-714566
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE:
Infantile spasms, also known as West syndrome, is an age-specific epileptic seizure. Most patients with this condition also exhibit delayed development. This study aimed to determine the effect of long-term prenatal stress on susceptibility to infantile spasms.METHODS:
We subjected pregnant rats to acute or chronic immobilization stress. Resulting offspring received N-methyl-D-aspartic acid (15 mg/kg, intraperitoneally) on postnatal day 15, and their behaviors were observed 75 minutes after injection. The expression of KCC2 and GAD67 was also determined using immunohistochemistry.RESULTS:
Exposure to long-term prenatal stress increased the frequency of spasms and decreased the latency to onset of spasms compared with offspring exposed to short-term prenatal stress. Expression of KCC2 and GAD67 also decreased in the group exposed to long-term prenatal stress compared with the group exposed to short-term prenatal stress.CONCLUSION:
Our study suggests that exposure to long-term prenatal stress results in increased susceptibility to seizures.Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Efeitos Tardios da Exposição Pré-Natal
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Convulsões
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Espasmo
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Espasmos Infantis
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Imuno-Histoquímica
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N-Metilaspartato
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Epilepsia
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Ácido gama-Aminobutírico
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Glutamato Descarboxilase
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Imobilização
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Korean Journal of Pediatrics
Ano de publicação:
2018
Tipo de documento:
Article