Expression of collagenases (matrix metalloproteinase-1, 8, 13) and tissue inhibitor of metalloproteinase-1 of retrodiscal tissue in temporomandibular joint disorder patients
Journal of the Korean Association of Oral and Maxillofacial Surgeons
; : 120-127, 2018.
Article
em En
| WPRIM
| ID: wpr-715070
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVES: The aim of this study was to reveal how collagenases (matrix metalloproteinase [MMP]-1, 8, 13) and tissue inhibitor of metalloproteinase 1 (TIMP-1) are expressed in immunohistochemistry of retrodiscal tissue in temporomandibular joint disorder patients. MATERIALS AND METHODS: This study was conducted on 39 patients who underwent discoplasty or discectomy. Immunohistochemical staining was undertaken and expression levels of MMP-1, 8, 13, and TIMP-1 were evaluated. The status of internal derangement of disc, osteoarthritis, and joint effusion were analyzed using magnetic resonance imaging (MRI). Disc status observed during operation was also categorized. RESULTS: The more severe disc derangement was observed on MRI, the more increased expression of MMPs and TIMP-1 appeared. Regarding MMP-13 expression, 86.7% of late-stage disc displacement patients showed grade II or III. Expression level of MMPs or TIMP was not statistically significant associated with joint effusion level. In perforation and/or adhesion groups, all patients showed grade II or III expression of MMP-13. Once perforation occurred, MMP-13 showed increased expression with statistical significance. CONCLUSION: MMP-1 and MMP-13 expression seem to be related to progression of osteoarthritis whereas MMP-8 does not seem to have a specific role with regard to temporomandibular joint disorders. TIMP-1 is considered to be partly related to internal derangement rather than osteoarthritis, but it is not significant.
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Índice:
WPRIM
Assunto principal:
Osteoartrite
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Articulação Temporomandibular
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Imuno-Histoquímica
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Imageamento por Ressonância Magnética
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Transtornos da Articulação Temporomandibular
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Colagenases
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Discotomia
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Inibidor Tecidual de Metaloproteinase-1
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Metaloproteinases da Matriz
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Articulações
Limite:
Humans
Idioma:
En
Revista:
Journal of the Korean Association of Oral and Maxillofacial Surgeons
Ano de publicação:
2018
Tipo de documento:
Article