Mouse models for hepatitis B virus research / 한국실험동물학회지
Laboratory Animal Research
; : 85-91, 2018.
Article
em En
| WPRIM
| ID: wpr-717163
Biblioteca responsável:
WPRO
ABSTRACT
Hepatitis B virus (HBV) infection remains a major global health problem; indeed, there are 250 million carriers worldwide. The host range of HBV is narrow; therefore, few primates are susceptible to HBV infection. However, ethical constraints, high cost, and large size limit the use of primates as suitable animal models. Thus, in vivo testing of therapies that target HBV has been hampered by the lack of an appropriate in vivo research model. To address this, mouse model systems of HBV are being developed and several are used for studying HBV in vivo. In this review, we summarize the currently available mouse models, including HBV transgenic mice, hydrodynamic injection-mediated HBV replicon delivery systems, adeno-associated virus-mediated HBV replicon delivery systems, and human liver chimeric mouse models. These developed (or being developed) mouse model systems are promising and should be useful tools for studying HBV.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Primatas
/
Replicon
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Camundongos Transgênicos
/
Vírus da Hepatite B
/
Saúde Global
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Modelos Animais
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Hidrodinâmica
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Especificidade de Hospedeiro
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Hepatite
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Hepatite B
Limite:
Animals
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Humans
Idioma:
En
Revista:
Laboratory Animal Research
Ano de publicação:
2018
Tipo de documento:
Article