Delayed Terminal Ileal Perforation in a Relapsed/Refractory B-Cell Lymphoma Patient with Rapid Remission Following Chimeric Antigen Receptor T-Cell Therapy / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
; : 1462-1466, 2018.
Article
em En
| WPRIM
| ID: wpr-717507
Biblioteca responsável:
WPRO
ABSTRACT
Chimeric antigen receptor T-cell strategy targeting CD19 (CART19) has prominent anti-tumor effect for relapsed/refractory B-cell lymphomas. CART19-associated complications have been gradually recognized, however, late-onset complications have not been extensively studied. Herein, for the first time we report a diffuse large B-cell lymphoma patient with terminal ileum involvement obtained rapid remission and developed spontaneous terminal ileal perforation 38 days following CART19 infusion. The late-onset perforation reminds us that, for the safety of CART treatment, more cautions are warranted for the management of delayed GI complications.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Linfócitos B
/
Receptores de Antígenos
/
Linfócitos T
/
Linfoma de Células B
/
Íleo
Limite:
Humans
Idioma:
En
Revista:
Cancer Research and Treatment
Ano de publicação:
2018
Tipo de documento:
Article