PI3K-Akt-Wnt Pathway Is Implicated in Exercise-Induced Improvement of Short-term Memory in Cerebral Palsy Rats / 대한배뇨장애요실금학회지
International Neurourology Journal
; : S156-S164, 2018.
Article
em En
| WPRIM
| ID: wpr-717675
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE:
Maternal lipopolysaccharide (LPS) injection induces neurodevelopmental disorders, such as cerebral palsy. Exercise activates phosphatidylinositol 3-kinase (PI3K)-protein kinase B (Akt) signaling pathway that enhances neurogenesis. Wnt ligands are also implicated in the hippocampal neurogenesis and synaptic plasticity. Glycogen synthase kinase-3β (GSK-3β) is a downstream molecule of Akt, and GSK-3β is known to modulate hippocampal neurogenesis negatively.METHODS:
Cerebral palsy was made by maternal LPS-injection. On the 5 weeks after birth, treadmill running was applied to the rat pups of the exercise groups, for 30 minutes, 5 times a week during 6 weeks.RESULTS:
Treadmill running alleviated short-term memory impairments of the cerebral palsy rat pups. Hippocampal cell proliferation was increased and hippocampal apoptosis was suppressed by treadmill running in the cerebral palsy rat pups. Hippocampal phosphorylated-PI3K/PI3K ratio, phosphorylated-Akt/Akt ratio, and Wnt expression were enhanced by treadmill running in the cerebral palsy rat pups. In contrast, hippocampal phosphorylated-GSK-3β/GSK-3β ratio and β-catenin expression were suppressed by treadmill running in the cerebral palsy rat pups.CONCLUSIONS:
The results of this study showed that short-term memory improvement due to treadmill running in cerebral palsy occurs via activation of the PI3K-Akt-Wnt pathway.Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Fosfotransferases
/
Corrida
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Paralisia Cerebral
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Glicogênio Sintase
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Apoptose
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Parto
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Proliferação de Células
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Proteínas Proto-Oncogênicas c-akt
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Neurogênese
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Fosfatidilinositol 3-Quinase
Limite:
Animals
Idioma:
En
Revista:
International Neurourology Journal
Ano de publicação:
2018
Tipo de documento:
Article