Anti-Tumor Necrosis Factor Therapy in Intestinal Behçet's Disease
Gut and Liver
; : 623-632, 2018.
Article
em En
| WPRIM
| ID: wpr-718125
Biblioteca responsável:
WPRO
ABSTRACT
Intestinal Behçet's disease is a rare, immune-mediated chronic intestinal inflammatory disease; therefore, clinical trials to optimize the management and treatment of patients are scarce. Moreover, intestinal Behçet's disease is difficult to treat and often requires surgery because of the failure of conventional medical treatment. Administration of anti-tumor necrosis factor–α, a potential therapeutic strategy, is currently under active clinical investigation, and evidence of its effectiveness for both intestinal Behçet's disease and inflammatory bowel diseases has been accumulating. Here, we review updated data on current experiences and outcomes after the administration of anti-tumor necrosis factor–α for the treatment of intestinal Behçet's disease. In addition to infliximab and adalimumab, which are the most commonly used agents, we describe agents such as golimumab, etanercept, and certolizumab pegol, which have recently been shown to be effective in refractory intestinal Behçet's disease. This review also discusses safety issues associated with anti-tumor necrosis factor–α, including vulnerability to infections and malignancy.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Doenças Inflamatórias Intestinais
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Síndrome de Behçet
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Certolizumab Pegol
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Adalimumab
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Infliximab
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Etanercepte
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Necrose
Limite:
Humans
Idioma:
En
Revista:
Gut and Liver
Ano de publicação:
2018
Tipo de documento:
Article