Comparison of Adverse Events between High-intensity and Moderate- to Low-intensity Statin Group
Korean Journal of Clinical Pharmacy
; : 293-299, 2018.
Article
em Ko
| WPRIM
| ID: wpr-718448
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND:
3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) effectively reduce serum levels of low-density lipoprotein (LDL) and total cholesterol. High-intensity statins are recommended for all patients aged ≤75 with clinical atherosclerotic cardiovascular disease (ASCVD), diabetes mellitus aged 40–75 with ≥7.5% estimated 10-year ASCVD risk and LDL-C ≥190 mg/ dL. High-intensity statins associated with more frequent adverse events (AEs) compared to moderate- to low-intensity statins. The aim of this study was to compare AEs between high-intensity and moderate- to low-intensity statin group using the Korea Adverse Event Reporting System (KAERS) database.METHODS:
Adults (≥18 years) with statin-associated AEs from July 2009-June 2014 were included. Only AEs classified as “certain”, “probable” and “possible” based on the WHO-Uppsala Monitoring Center criteria were analyzed.RESULTS:
In total, 247 AEs from 196 patients [high-intensity statin group (HG), n = 25 (13%); moderate- to lowintensity statin group (MLG), n = 171 (87%)] were included. Mean age was higher in HG compared with MLG (67 ± 14 vs 62 ± 12). The HG showed a significant higher frequency of liver/biliary system disorders (37% vs 14%, p = 0.001). Hepatic function abnormal was reported more frequently in HG compared to MLG (26% vs 9%, p = 0.006).CONCLUSION:
According to KAERS data, liver/biliary system disorders were more frequently reported in HG compared to MLG.Palavras-chave
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Índice:
WPRIM
Assunto principal:
Oxirredutases
/
Doenças Cardiovasculares
/
Colesterol
/
Coenzima A
/
Inibidores de Hidroximetilglutaril-CoA Redutases
/
Diabetes Mellitus
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Coreia (Geográfico)
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Lipoproteínas
Limite:
Adult
/
Humans
País/Região como assunto:
Asia
Idioma:
Ko
Revista:
Korean Journal of Clinical Pharmacy
Ano de publicação:
2018
Tipo de documento:
Article