Concurrent Use of Nefopam vs. Ketorolac with Opioid Analgesic for Post-operative Pain Management
Korean Journal of Clinical Pharmacy
; : 279-284, 2018.
Article
em En
| WPRIM
| ID: wpr-718450
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE:
To compare the analgesic effects and adverse drug reactions (ADRs) of fentanyl intravenous patient-controlled analgesia (ivPCA) with nefopam, a centrally acting analgesic agent with demonstrated opioid sparing activity, as compared to ketorolac in a tertiary teaching hospital.METHODS:
A retrospective evaluation of electronic medical records was conducted on patient records including either nefopam or ketorolac with opioid ivPCA for post-operative pain management in general surgery department from January to December 2014. The status of pain control and ADRs were collected.RESULTS:
Out of 6,330 general surgery cases, nefopam was given in 153 prescriptions (6.9%) and ketorolac in 81 prescriptions (3.6%). The level of pain control was not different between two groups (70.9% vs. 75.3%; p = 0.51), but ADRs were more frequently reported in nefopam group (9.8% vs. 2.5%; p < 0.05). New ADRs of hot flushes (n = 1) and paresthesia in hands (n = 1) were reported in nefopam group and they were unlisted in the approved package insert. No serious ADRs were reported in both groups.CONCLUSION:
Our findings presented that nefopam showed a similar analgesic effect and higher ADR rates compared to ketorolac as an adjuvant to fentanyl iv PCA for postoperative pain management in general surgery patients in South Korea.Palavras-chave
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Índice:
WPRIM
Assunto principal:
Dor Pós-Operatória
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Parestesia
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Rotulagem de Produtos
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Anafilaxia Cutânea Passiva
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Fentanila
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Estudos Retrospectivos
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Analgesia Controlada pelo Paciente
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Cetorolaco
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Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos
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Prescrições
Tipo de estudo:
Observational_studies
Limite:
Humans
País/Região como assunto:
Asia
Idioma:
En
Revista:
Korean Journal of Clinical Pharmacy
Ano de publicação:
2018
Tipo de documento:
Article