Amelioration of experimental autoimmune encephalomyelitis by Ishige okamurae / 대한해부학회지
Anatomy & Cell Biology
; : 292-298, 2018.
Article
em En
| WPRIM
| ID: wpr-718950
Biblioteca responsável:
WPRO
ABSTRACT
Experimental autoimmune encephalomyelitis (EAE) is a T-cell-mediated autoimmune central nervous system disease characterized by inflammation with oxidative stress. The aim of this study was to evaluate an anti-inflammatory effect of Ishige okamurae on EAE-induced paralysis in rats. An ethanolic extract of I. okamurae significantly delayed the first onset and reduced the duration and severity of hind-limb paralysis. The neuropathological and immunohistochemical findings in the spinal cord were in agreement with these clinical results. T-cell proliferation assay revealed that the ethyl-acetate fraction of I. okamurae suppressed the proliferation of myelin basic protein reactive T cells from EAE affected rats. Flow cytometric analysis showed TCRαβ+ T cells was significantly reduced in the spleen of EAE rats with I. okamurae treatment with concurrent decrease of inflammatory mediators including tumor necrosis factor-α and cyclooxygenase-2. Collectively, it is postulated that I. okamurae ameliorates EAE paralysis with suppression of T-cell proliferation as well as decrease of pro-inflammatory mediators as far as rat EAE is concerned.
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Índice:
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Assunto principal:
Paralisia
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Medula Espinal
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Baço
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Linfócitos T
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Sistema Nervoso Central
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Estresse Oxidativo
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Etanol
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Proteína Básica da Mielina
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Encefalomielite Autoimune Experimental
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Ciclo-Oxigenase 2
Limite:
Animals
Idioma:
En
Revista:
Anatomy & Cell Biology
Ano de publicação:
2018
Tipo de documento:
Article