FLT3 Internal Tandem Duplication in Acute Myeloid Leukemia with Normal Karyotype
Korean Journal of Hematology
; : 250-257, 2007.
Article
em En
| WPRIM
| ID: wpr-720788
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND:
The presence of FLT3 internal tandem dupulication (FLT3/ITD) in patients with acute myeloid leukemia (AML) with normal karyotype was investigated in order to evaluate its clinical and prognostic significance.METHODS:
The FLT3/ITD was studied by PCR assay in bone marrow samples obtained from 123 patients at diagnosis. Ninety patients who received intensive induction chemotherapy were evaluated.RESULTS:
Of total 123 patients, forty-seven (38.2%) demonstrated the aberrant FLT3/ITD. Patients with FLT3/ITD had significantly higher leukocyte counts at presentation than did patients without FLT3/ITD (P=0.04). By multivariate analysis, the FLT3/ITD was an independent prognostic factor of leukemic-free survival (LFS) (P=0.01) in AML patients with normal karyotype.CONCLUSION:
This study demonstrated that the presence of the FLT3/ITD was a significant factor for poor prognosis in AML patients with normal karyotype.Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Prognóstico
/
Medula Óssea
/
Leucemia Mieloide Aguda
/
Reação em Cadeia da Polimerase
/
Análise Multivariada
/
Diagnóstico
/
Quimioterapia de Indução
/
Cariótipo
/
Contagem de Leucócitos
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Korean Journal of Hematology
Ano de publicação:
2007
Tipo de documento:
Article