The Efficacy and Adverse Effect of Hydroxyurea as Compared with Anagrelide in Essential Thrombocythemia
Korean Journal of Hematology
; : 83-88, 2008.
Article
em Ko
| WPRIM
| ID: wpr-720807
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND: Although the platelet count may not always correlate with the risk of thrombosis, there is evidence that a strict control of the platelet count decreases the incidence of thrombotic and hemorrhagic complications. However, it is difficult to select an appropriate platelet-lowering agent. This retrospective study was performed to assess the efficacy and adverse effect of the use of hydroxyurea and anagrelide for patients with essential thrombocythemia. METHODS: Sixty patients with essential thrombocythemia received either hydroxyurea (n=30) or anagrelide (n=30). Early responses and adverse effects of hydroxyurea and anagrelide in the patients were retrospectively analyzed. RESULTS: Treatment with anagrelide or hydroxyurea resulted in a rapid decrease of the platelet count within two weeks. The response rates after treatment with hydroxyurea and anagrelide were 83% and 77%, respectively. As compared with patients treated with hydroxyurea, patients treated with anagrelide presented with adverse effects such as headache palpitation was also frequently noticed (P=0.001). However, serious hemorrhage (n=2) and transformation to leukemia (n=1) occurred in patients treated with hydroxyurea. CONCLUSION: Both anagrelide and hydroxyurea were effective and well-tolerated agents for the reduction of the platelet count. Long-term efficacy and adverse effects of the drugs remain to be determined.
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Texto completo:
1
Índice:
WPRIM
Assunto principal:
Contagem de Plaquetas
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Quinazolinas
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Trombose
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Leucemia
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Incidência
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Estudos Retrospectivos
/
Cefaleia
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Hemorragia
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Trombocitemia Essencial
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Hidroxiureia
Tipo de estudo:
Incidence_studies
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Observational_studies
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Prognostic_studies
Limite:
Humans
Idioma:
Ko
Revista:
Korean Journal of Hematology
Ano de publicação:
2008
Tipo de documento:
Article