Effects of Exercise on Neuropathic Pain in an Experimental Model of Peripheral Neuropathy
Journal of the Korean Academy of Rehabilitation Medicine
; : 224-232, 1999.
Article
em Ko
| WPRIM
| ID: wpr-724199
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE: The purpose of this study was to evaluate the short- and long-term effects of exercise on neuropathic pain. METHOD: Pain responses between rats in the exercise and control groups were compared to evaluate the effects of exercise in neuropathic pain. Materials consisted of 30 male Sprague-Dawley rats (8 weeks old, 180~200 g), which were divided into an exercise group (n=15) and a control group (n=15). Neuropathic pain was produced by partially injuring the nerve innervating the tail. Running exercise was given on a Rota-rod treadmill exercise machine for 3 weeks (3.1 Km/day, 6 cycle of 9 minutes exercise and 1 minute rest). Behavioral reactions to mechanical allodynia were checked using a von Frey hairs of 2.0 g (19.6 mN) bending force at 10 minutes, 1 hour and 24 hours post-exercise to evaluate the short term effects of exercise. Behavioral reactions to mechanical and thermal allodynia with 4 degrees C or 40 degrees C were evaluated 7, 14, 21 and 28 days following exercise. RESULT: The exercise group exhibited less tail-flick frequencies to mechanical stimulation from 58.8+/-6.8% to 41.1+/-5.4%, 37.6+/-13.2% at 1 and 24 hours post-exercise compared to the control group, but there was no significant difference between the groups at weeks 1 through 4. In the exercise group, the decrease of tail-flick frequencies were blocked by naloxone (2 mg/kg i.p.). It is suggested that long-lasting muscle exercise (e.g. running) which influences central endorphin mechanisms giving analgetic effects. CONCLUSION: The results of this study support the hypothesis that the exercise can reduce neuropathic pain in the acute stage.
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Texto completo:
1
Índice:
WPRIM
Assunto principal:
Corrida
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Cauda
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Endorfinas
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Ratos Sprague-Dawley
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Doenças do Sistema Nervoso Periférico
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Cabelo
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Hiperalgesia
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Modelos Teóricos
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Naloxona
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Neuralgia
Limite:
Animals
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Humans
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Male
Idioma:
Ko
Revista:
Journal of the Korean Academy of Rehabilitation Medicine
Ano de publicação:
1999
Tipo de documento:
Article