Lipidomic analysis of plasma lipids composition changes in septic mice
The Korean Journal of Physiology and Pharmacology
; : 399-408, 2018.
Article
em En
| WPRIM
| ID: wpr-727579
Biblioteca responsável:
WPRO
ABSTRACT
A lipidomic study on extensive plasma lipids in bacterial peritonitis (cecal ligation and puncture, CLP)-induced sepsis in mice was done at 24 h post-CLP. The effects of administration of lysophosphatidylcholine (LPC) and lysophosphatidic acid (LPA), compounds known to have beneficial effects in CLP, on the sepsis-induced plasma lipid changes were also examined. Among the 147 plasma lipid species from 13 lipid subgroups (fatty acid [FA], LPA, LPC, lysophosphatidylethanolamine [LPE], phosphatidic acid [PA], phosphatidylcholine [PC], phosphatidylethanolamine [PE], phosphatidylinositol [PI], monoacylglyceride [MG], diacylglyceride [DG], triacylglyceride [TG], sphingomyelin [SM], and ceramide [Cer]) analyzed in this study, 40 and 70 species were increased, and decreased, respectively, in the CLP mice. Treatments with LPC and LPA affected 14 species from 7 subgroups, and 25 species from 9 subgroups, respectively. These results could contribute to finding the much needed reliable biomarkers of sepsis.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Peritonite
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Ácidos Fosfatídicos
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Fosfatidilcolinas
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Fosfatidilinositóis
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Plasma
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Lisofosfatidilcolinas
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Biomarcadores
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Punções
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Sepse
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Ligadura
Limite:
Animals
Idioma:
En
Revista:
The Korean Journal of Physiology and Pharmacology
Ano de publicação:
2018
Tipo de documento:
Article