Short-term Treatment of Daumone Improves Hepatic Inflammation in Aged Mice
The Korean Journal of Physiology and Pharmacology
; : 269-274, 2015.
Article
em En
| WPRIM
| ID: wpr-728514
Biblioteca responsável:
WPRO
ABSTRACT
Chronic inflammation has been proposed as one of the main molecular mechanisms of aging and age-related diseases. Although evidence in humans is limited, short-term calorie restriction (CR) has been shown to have anti-inflammatory effects in aged experimental animals. We reported on the long-term treatment of daumone, a synthetic pheromone secreted by Caenorhabditis elegans in an energy deficient environment, extends the life-span and attenuates liver injury in aged mice. The present study examined whether late onset short-term treatment of daumone exerts anti-inflammatory effects in the livers of aged mice. Daumone was administered orally at doses of 2 or 20 mg/kg/day for 5 weeks to 24-month-old male C57BL/6J mice. Increased liver macrophage infiltration and gene expression of proinflammatory cytokines in aged mice were significantly attenuated by daumone treatment, suggesting that short-term oral administration of daumone may have hepatoprotective effects. Daumone also dose-dependently suppressed tumor necrosis factor-alpha (TNF-alpha)-induced nuclear factor-kappaB (NF-kappaB) phosphorylation in HepG2 cells. The present data demonstrated that short-term treatment of daumone has anti-inflammatory effects in aged mouse livers possibly through suppression of NF-kappaB signaling and suggest that daumone may become a lead compound targeting aging and age-associated diseases.
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Texto completo:
1
Índice:
WPRIM
Assunto principal:
Feromônios
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Fosforilação
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Envelhecimento
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Expressão Gênica
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Administração Oral
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Citocinas
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NF-kappa B
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Fator de Necrose Tumoral alfa
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Caenorhabditis elegans
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Células Hep G2
Limite:
Animals
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Humans
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Male
Idioma:
En
Revista:
The Korean Journal of Physiology and Pharmacology
Ano de publicação:
2015
Tipo de documento:
Article