Quantitative Structure Activity Relationship between Diazabicyclo4.2.0octanes Derivatives and Nicotinic Acetylcholine Receptor Agonists
The Korean Journal of Physiology and Pharmacology
; : 55-59, 2009.
Article
em En
| WPRIM
| ID: wpr-728655
Biblioteca responsável:
WPRO
ABSTRACT
Three dimensional quantitative structure activity relationship between diazabicyclo[4.2.0]octanes and nicotinic acetylcholine receptor (h alpha4beta2 and h alpha3beta4) agonists was studied using comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA). From 11 CoMFA and CoMSIA models, CoMSIA with steric and electrostatic fields gave the best predictive models (q2=0.926 and 0.945, r2(ncv)=0.983 and 0.988). This study can be used to develop potent h alpha4beta2 receptor agonists with low activity on h alpha3beta4 subtype.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Receptores Nicotínicos
/
Relação Quantitativa Estrutura-Atividade
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
The Korean Journal of Physiology and Pharmacology
Ano de publicação:
2009
Tipo de documento:
Article