PromoterWizard: An Integrated Promoter Prediction Program Using Hybrid Methods
Genomics & Informatics
; : 194-196, 2011.
Article
em En
| WPRIM
| ID: wpr-73129
Biblioteca responsável:
WPRO
ABSTRACT
Promoter prediction is a very important problem and is closely related to the main problems of bioinformatics such as the construction of gene regulatory networks and gene function annotation. In this context, we developed an integrated promoter prediction program using hybrid methods, PromoterWizard, which can be employed to detect the core promoter region and the transcription start site (TSS) in vertebrate genomic DNA sequences, an issue of obvious importance for genome annotation efforts. PromoterWizard consists of three main modules and two auxiliary modules. The three main modules include CDRM (Composite Dependency Reflecting Model) module, SVM (Support Vector Machine) module, and ICM (Interpolated Context Model) module. The two auxiliary modules are CpG Island Detector and GCPlot that may contribute to improving the predictive accuracy of the three main modules and facilitating human curator to decide on the final annotation.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Vertebrados
/
Sequência de Bases
/
Quimera
/
Regiões Promotoras Genéticas
/
Genoma
/
Ilhas de CpG
/
Biologia Computacional
/
Sítio de Iniciação de Transcrição
/
Dependência Psicológica
/
Redes Reguladoras de Genes
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Genomics & Informatics
Ano de publicação:
2011
Tipo de documento:
Article