HisCoM-GGI: Software for Hierarchical Structural Component Analysis of Gene-Gene Interactions
Genomics & Informatics
; : e38-2018.
Article
em En
| WPRIM
| ID: wpr-739675
Biblioteca responsável:
WPRO
ABSTRACT
Gene-gene interaction (GGI) analysis is known to play an important role in explaining missing heritability. Many previous studies have already proposed software to analyze GGI, but most methods focus on a binary phenotype in a case-control design. In this study, we developed “Hierarchical structural CoMponent analysis of Gene-Gene Interactions” (HisCoM-GGI) software for GGI analysis with a continuous phenotype. The HisCoM-GGI method considers hierarchical structural relationships between genes and single nucleotide polymorphisms (SNPs), enabling both gene-level and SNP-level interaction analysis in a single model. Furthermore, this software accepts various types of genomic data and supports data management and multithreading to improve the efficiency of genome-wide association study data analysis. We expect that HisCoM-GGI software will provide advanced accessibility to researchers in genetic interaction studies and a more effective way to understand biological mechanisms of complex diseases.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Fenótipo
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Estudos de Casos e Controles
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Estatística como Assunto
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Polimorfismo de Nucleotídeo Único
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Estudo de Associação Genômica Ampla
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Métodos
Tipo de estudo:
Observational_studies
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Risk_factors_studies
Idioma:
En
Revista:
Genomics & Informatics
Ano de publicação:
2018
Tipo de documento:
Article