Out-sourcing for Trans-presentation: Assessing T Cell Intrinsic and Extrinsic IL-15 Expression with Il15 Gene Reporter Mice
Immune Network
; : e13-2018.
Article
em En
| WPRIM
| ID: wpr-740199
Biblioteca responsável:
WPRO
ABSTRACT
IL-15 is a cytokine of the common γ-chain family that is critical for natural killer (NK), invariant natural killer T (iNKT), and CD8 memory T cell development and homeostasis. The role of IL-15 in regulating effector T cell subsets, however, remains incompletely understood. IL-15 is mostly expressed by stromal cells, myeloid cells, and dendritic cells (DCs). Whether T cells themselves can express IL-15, and if so, whether such T cell-derived IL-15 could play an autocrine role in T cells are interesting questions that were previously addressed but answered with mixed results. Recently, three independent studies described the generation of IL-15 reporter mice which facilitated the identification of IL-15-producing cells and helped to clarify the role of IL-15 both in vitro and in vivo. Here, we review the findings of these studies and place them in context of recent reports that examined T cell-intrinsic IL-15 expression during CD4 effector T cell differentiation.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Técnicas In Vitro
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Células Dendríticas
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Linfócitos T
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Diferenciação Celular
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Subpopulações de Linfócitos T
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Células Estromais
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Receptores de Citocinas
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Interleucina-15
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Células Mieloides
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Células Th17
Tipo de estudo:
Prognostic_studies
Limite:
Animals
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Humans
Idioma:
En
Revista:
Immune Network
Ano de publicação:
2018
Tipo de documento:
Article