Effect of Sasa quelpaertensis Nakai Extracts and its Constituent p-coumaric Acid on the Apoptosis of Human Cancer Cell Lines
Natural Product Sciences
; : 293-297, 2018.
Article
em En
| WPRIM
| ID: wpr-741627
Biblioteca responsável:
WPRO
ABSTRACT
Sasa quelpaertensis Nakai leaves contain a mixture of polysaccharides, amino acids, and polyphenols, which mediate various biological activities. For efficient utilization of its leaf, we reported the preparation procedure for phytochemical-rich extract (PRE) using the leaf residue, which was by-product of hot water extraction. This study was undertaken to evaluate the effects of PRE and its major constituent, p-coumaric acid,on the growth of several human cancer cell lines (MKN-74, MKN-45, SNU-1, SNU-16, and HL-60). The ethyl acetate fraction of PRE and p-coumaric acid significantly inhibited the proliferation of MKN-74 and HL-60 cells, respectively, and induced cell apoptosis, down-regulated Bcl-2 and poly (ADP-ribose) polymerase levels, and up-regulated those of Bax and caspase-3. These results show the potential utility of S. quelpaertensis Nakai leaves in cancer prevention.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Polissacarídeos
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Água
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Linhagem Celular
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Apoptose
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Células HL-60
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Sasa
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Caspase 3
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Polifenóis
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Compostos Fitoquímicos
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Aminoácidos
Limite:
Humans
Idioma:
En
Revista:
Natural Product Sciences
Ano de publicação:
2018
Tipo de documento:
Article