Correlation of retinopathy and serum cystatin C in patients with primary hypertension / 中国基层医药

ABSTRACT

Objective To analyze the features of hypertensive retinopathy (HRP),and to evaluate the correlation of serum cystatin C (Cys-C) and retinopathy in patients with primary hypertension.Methods From July 2015 to October 2017,280 cases of primary hypertension in the Second People's Hospital of Ji'nan were recruited to receive fundus examination by funduscopy and eye-ground photography.Based on the findings,4 groups were established according to Chinese Ophthalmology (Third Edition) classification standard,normal,mild,moderate and malignant four levels.Clinical courses were monitored and Cys-C levels were determined.Results There were 204 cases of HRP,accounting for 72.86％.Compared with that of the normal fundus group (0.76 ±0.12)mg/L,the serum Cys-C level of the mild HRP group was (0.82 ± 0.19)mg/L,the difference was statistically significant (t =2.424,P ＜ 0.05).The serum Cys-C levels of the moderate HRP group and severe HRP group were (2.37 ± 0.13) mg/L and (3.24 ± 0.45) mg/L,respectively,the differences were statistically significant compared with that of the control group (t =80.917,42.153,all p ＜ 0.01).Conclusion The severity of HRP is positively correlated with Cys-C.