Diagnosis progress of pediatric myelodysplastic syndromes / 肿瘤研究与临床

ABSTRACT

Myelodysplastic syndrome (MDS) is a kind of clone diseases originating from hematopoietic stem/progenitor cells, and it has a high risk of transforming into acute myeloid leukemia (AML). The incidence of childhood MDS is low, which shows a big difference between pediatric MDS and adult MDS in morphology, immunology, cytogenetics and molecular biology. Childhood MDS has some unique biological characteristics, and thus, it is very difficult to diagnose and treat. This article reviews the progress of pediatric MDS.