Clinical significance and relationship between HIF-1alpha, COX-2, VEGF and microvessel density expression in laryngeal carcinoma / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
; (24): 820-822, 2010.
Article
em Zh
| WPRIM
| ID: wpr-747487
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE@#To evaluate the role of HIF-1alpha, COX-2, VEGF proteins and Microvessel density in angiogenesis and metastasis of laryngeal carcinoma.@*METHOD@#Surgically resected specimens of 64 laryngeal carcinomas were studied by immunohistochemical staining for HIF-1alpha protein, COX-2 protein, VEGF and MVD.@*RESULT@#Positive expressions of HIF-1alpha, COX-2 protein and VEGF were found in 65.63%, 68.75% and 71.88% of laryngeal carcinoma specimens, respectively. The mean MVD in this series was 35.79 +/- 9.49. The expression of HIF-1alpha, COX-2 and VEGF positively correlated with MVD expression. There was a positive relationship between HIF-1alpha, COX-2 and VEGF expression. The microvessel density (MVD) in HIF-1alpha, COX-2 and VEGF positive tumors was significantly higher in patients with cervical lymph node metastases than that in patients without metastases.@*CONCLUSION@#HIF-1alpha, COX-2 and VEGF proteins may play an important role in the angiogenesis of laryngeal carcinoma. HIF-1alpha regulate the expression and function of its downstream target genes (COX-2 and VEGF), which play a critical role in the angiogenesis of laryngeal carcinoma, metastases in the process of laryngeal cancer cell spreading to cervical lymph nodes.
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Índice:
WPRIM
Assunto principal:
Patologia
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Carcinoma de Células Escamosas
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Neoplasias Laríngeas
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Fator A de Crescimento do Endotélio Vascular
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Ciclo-Oxigenase 2
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Subunidade alfa do Fator 1 Induzível por Hipóxia
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Microvasos
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Metabolismo
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Estadiamento de Neoplasias
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Neovascularização Patológica
Limite:
Aged
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Aged80
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Ano de publicação:
2010
Tipo de documento:
Article