Expression and significance of DNA-dependent protein kinase in human laryngeal squamous cell carcinoma / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
; (24): 1641-1644, 2014.
Article
em Zh
| WPRIM
| ID: wpr-747675
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE@#To study the expression of DNA-dependent protein kinase (DNA-PK) in human laryngeal squamous cell carcinoma (LSCC) and normal laryngeal mucosa (NLM), and to analysize the relationship between the expression and the clinicopathologic parameters of LSCC.@*METHOD@#Immunohistochemical technique (Envision) was used to detect the expression of DNA-PK in 64 cases of LSCC and 15 cases of NLM. To investigate an investigation was conducted on the relationship between the expression and clinico-pathological features of LSCC.@*RESULT@#DNA-PK was lowly expressed in NLM and highly expressed in LSCC,the positive rate of DNA-PK expression was 26.67% (4/15), 78.13% (50/64), respectively, and there was significant different difference between the two groups (P 0.05).@*CONCLUSION@#DNA-PK may be involved in disease development of LSCC.
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Índice:
WPRIM
Assunto principal:
Patologia
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Carcinoma de Células Escamosas
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Neoplasias Laríngeas
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Proteína Quinase Ativada por DNA
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Carcinoma de Células Escamosas de Cabeça e Pescoço
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Neoplasias de Cabeça e Pescoço
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Mucosa Laríngea
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Laringe
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Linfonodos
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Metástase Linfática
Limite:
Aged
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Ano de publicação:
2014
Tipo de documento:
Article