Effect evaluation of allergen specific immunotherapy in patients with allergic rhinitis and asthma / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
; (24): 629-632, 2015.
Article
em Zh
| WPRIM
| ID: wpr-747747
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE@#To evaluate the effect of allergen specific immunotherapy (SIT) in patients with allergic rhinitis and asthma. METHOD A total of 68 patients with allergic rhinitis and asthma sensitized to dust mite were recruited into the study. They were randomly divided into two groups SIT group n = 34 and symptomatic therapy (ST) group n = 34. Patients in ST group received medication to treat, the symptoms, patients in SIT group received medication and 3 years of standardized allergen vaccine therapy. Evaluation index of therapy includes rhinitis symptoms score, asthma symptoms score, drug score, skin prick test, serum specificity IgE (sIgE) , peripheral eosinophil (Eos) counting, lung function. The new sensitinogen rate was also assessed.@*RESULT@#Clinical symptom scores, drug scores, lung function, blood eosinophil numbers and skin test result were all improved significantly after 3-year treatment in SIT group compared to those in ST group (P < 0.01). Although the level of serum slgE was decreased,there exited no statistic diferences between two groups. Only 8.8% patients have the new sensitization in SIT group, and 52.9% in ST group. There were no serious adverse reactions in treatment process.@*CONCLUSION@#SIT for patients with AR and asthma can obtain excellent clinical efficacy.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Asma
/
Sangue
/
Imunoglobulina E
/
Testes Cutâneos
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Sensibilidade e Especificidade
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Dessensibilização Imunológica
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Pyroglyphidae
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Tratamento Farmacológico
/
Eosinófilos
/
Rinite Alérgica
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
/
Humans
Idioma:
Zh
Revista:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Ano de publicação:
2015
Tipo de documento:
Article