Effects of IAA/HRP on the proliferation and apoptosis of SACC-83 cells / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
; (24): 31-34, 2016.
Article
em Zh
| WPRIM
| ID: wpr-749734
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE@#To study the effect of IAA/HRP on the proliferation and apoptosis of human SACC-83 cells in vitro,and its molecular mechanism.@*METHOD@#The rate of proliferation inhibition was determined by CCK-8 assay, the apoptosis-related gene Caspase-3 and Livinα mRNA and protein expression levels were measured by real-time PCR and Western blot.@*RESULT@#IAA/HRP could inhibit proliferation of SACC-83, which depending on the time and dosage (P < 0.05); can-up-regulate the Caspase-3 mRNA and protein expression levels and reduction of the mRNA and protein of the Livina expression, (both P < 0.05).@*CONCLUSION@#IAA/HRP can inhibit the proliferation and induce the apoptosis of SACC-83 cells, which may due to its regulation of the expression of Caspase-3 and Livinα mRNA expression.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Farmacologia
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Apoptose
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Linhagem Celular Tumoral
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Proteínas Adaptadoras de Transdução de Sinal
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Proliferação de Células
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Proteínas Inibidoras de Apoptose
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Caspase 3
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Ácidos Indolacéticos
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Metabolismo
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Proteínas de Neoplasias
Limite:
Humans
Idioma:
Zh
Revista:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Ano de publicação:
2016
Tipo de documento:
Article