Influence of metoprolol tartrate combined Danhong injection on ECG and serum BNP and sICAM—1 lev— els in patients with UAP of CHD

Cheng PENG; Chunmei QI; Jianqi FENG

ABSTRACT

Objective:

To explore therapeutic effect of metoprolol tartrate combined Danhong injection on patients with unstable angina pectoris of coronary heart disease (CHD—UAP) and its influence on serum levels of brain natri—uretic peptide (BNP) and soluble intercellular adhesion molecule—1 (sICAM—1).

Methods:

A total of 104 CHD—UAP patients treated in our hospital from Mar 2013 to May 2017 were randomly and equally divided into metoprolol group (received metoprolol based on routine treatment ) and combined treatment group (received Danhong injection based on metoprolol group) ,both groups were continuously treated for two weeks .Onset frequency and duration of angina pectoris ,serum BNP and sICAM—1 levels before and two weeks after treatment ,and incidence of adverse reactions were observed and compared between two groups .

Results:

After two—week ,clinical total effective rate (84. 62%vs.63. 46%) and ECG total effective rate (90.38% vs.69. 23%) of combined treatment group were significantly higher than those of metoprolol group , P＝0. 014 ,0.007. Compared with before treatment ,there were significant reductions in onset frequency and duration of angina pectoris and serum levels of BNP and sICAM—1 after two—week treatment in two groups , P＝0.001 all ;compared with metoprolol group after two—week treatment ,there were sig—nificant reductions in onset frequency [ (6. 03 ± 0.72 ) times／week vs .(2.69 ± 0.54 ) times／week ] and duration [ (4. 82 ± 0.51) min／time vs .(2. 65 ± 0.70) min／time] of angina pectoris ,serum levels of BNP [ (652.43 ± 97. 15) pg／ml vs .(536. 27 ± 95. 40) pg／ml] and sICAM—1 [ (105.27 ± 29.14) ng／L vs.(81.03 ± 26. 43) ng／L] in combined treatment group , P＝0. 001 all.There was no significant difference in incidence rate of adverse reactions between two groups , P＝0.506.

Conclusion:

Metoprolol tartrate combined Danhong injection possesses significant therapeu—tic effect on CHD—UAP patients .It can effectively reduce serum BNP and sICAM—1 levels ,onset frequency and du—ration of angina pectoris with high safety ,which is worth extending .