Progress in cellular senescence and organ fibrosis / 中华老年医学杂志

ABSTRACT

Fibrosis as a pathogenic mechanism occurs in numerous organs and diseases.Persistent and severe fibrosis affect the function of the organ.Organ fibrosis is an important cause of patient morbidity and mortality.Aging is considered as a strong risk factor for development of organ fibrosis.Organ fibrosis is age-related disease and cellular senescence plays an important role in the occurrence and development of fibrosis,which provides a new strategy for the treatment of fibrosis.This review is focused on the progress in cellular senescence and organ fibrosis.