Elevated plasma YKL-40 level is found in the dogs with cancer and is related to poor prognosis
Journal of Veterinary Science
; : e53-2019.
Article
em En
| WPRIM
| ID: wpr-758938
Biblioteca responsável:
WPRO
ABSTRACT
YKL-40, a secreted glycoprotein, may serve as an autoantigen, which mediates multiple inflammatory diseases and cancers. A high YKL-40 serum level is correlated with metastasis and poor survival in a variety of human cancers. However, the role of YKL-40 in dogs is still under evaluation. Herein, we examined the associations between plasma YKL-40 level and YKL-40 autoantibody (YAA) titers with malignancy and prognosis in canine cancer. Plasma levels of YKL-40 in healthy dogs (n = 20) and in dogs (n = 82) with cancer were evaluated using enzyme-linked immunosorbent assay. Our results indicated that plasma YKL-40 levels were significantly higher (p 180 pg/mL) than in the low YKL-40 group (< 180 pg/mL). The results imply that plasma YKL-40 levels might have the potential to be developed as a marker of malignancy progression and prognosis in canine cancers.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Plasma
/
Prognóstico
/
Recidiva
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Autoanticorpos
/
Autoantígenos
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Ensaio de Imunoadsorção Enzimática
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Glicoproteínas
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Metástase Neoplásica
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Journal of Veterinary Science
Ano de publicação:
2019
Tipo de documento:
Article