Neuroimmune interactions and kidney disease
Kidney Research and Clinical Practice
; : 282-294, 2019.
Article
em En
| WPRIM
| ID: wpr-759012
Biblioteca responsável:
WPRO
ABSTRACT
The autonomic nervous system plays critical roles in maintaining homeostasis in humans, directly regulating inflammation by altering the activity of the immune system. The cholinergic anti-inflammatory pathway is a well-studied neuroimmune interaction involving the vagus nerve. CD4-positive T cells expressing β2 adrenergic receptors and macrophages expressing the alpha 7 subunit of the nicotinic acetylcholine receptor in the spleen receive neurotransmitters such as norepinephrine and acetylcholine and are key mediators of the cholinergic anti-inflammatory pathway. Recent studies have demonstrated that vagus nerve stimulation, ultrasound, and restraint stress elicit protective effects against renal ischemia-reperfusion injury. These protective effects are induced primarily via activation of the cholinergic anti-inflammatory pathway. In addition to these immunological roles, nervous systems are directly related to homeostasis of renal physiology. Whole-kidney three-dimensional visualization using the tissue clearing technique CUBIC (clear, unobstructed brain/body imaging cocktails and computational analysis) has illustrated that renal sympathetic nerves are primarily distributed around arteries in the kidneys and denervated after ischemia-reperfusion injury. In contrast, artificial renal sympathetic denervation has a protective effect against kidney disease progression in murine models. Further studies are needed to elucidate how neural networks are involved in progression of kidney disease.
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Texto completo:
1
Índice:
WPRIM
Assunto principal:
Fisiologia
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Artérias
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Sistema Nervoso Autônomo
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Baço
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Simpatectomia
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Sistema Nervoso Simpático
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Nervo Vago
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Linfócitos T
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Traumatismo por Reperfusão
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Acetilcolina
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
En
Revista:
Kidney Research and Clinical Practice
Ano de publicação:
2019
Tipo de documento:
Article