Efficacy of Repeated Hepatic Arterial Infusion Chemotherapy in Advanced Hepatocellular Carcinoma with Portal Vein Tumor Thrombosis / 대한간학회지
The Korean Journal of Hepatology
; : 268-274, 2005.
Article
em Ko
| WPRIM
| ID: wpr-75926
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND/AIMS: The aim of this study is to elucidate the efficacy of repeated hepatic arterial infusion chemotherapy (HAIC) and different chemotherapeutic regimens for treating patients having advanced hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT). METHODS: From Jan. 1999 and Dec. 2003, a total of 103 patients diagnosed as having HCC with PVTT, but without extrahepatic spreading, were enrolled in this study. They were stratified into two groups. Group I (67 patients) received intraarterial cisplatin (CDDP, 80 mg/m2 for 2 hours on Day 1), Group II (36 patients) received intraarterial CDDP (60 mg/m2 for 2 hours on Day 2) and 5-fluorouracil (5-FU, 500 mg/m2 for 5 hours on Day 1-3). They were scheduled to receive at least three consecutive courses of the HAIC at 1 month intervals. RESULTS: Among the 66 patients who completed the protocol, one (2.5%) and seven (17.5%) patients of group I, and one (3.8%) and four (15.4%) of group II, exhibited complete and partial responses, respectively. The median survival period of all the patients was 6 months. Group II showed a tendency to improve the median survival compared to group I (8.5 vs 5.0 months, respectively, P=0.45). The most common adverse reaction was nausea (58.2%). However, an elevation of the total bilirubin level was more frequent in Group I than in Group II (61.3% vs 20.7%, respectively, P<0.05). CONCLUSIONS: Repeated HAIC using CDDP achieved favorable results in a few patients with HCC with PVTT, and additional 5-FU may be useful.
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Texto completo:
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Índice:
WPRIM
Assunto principal:
Veia Porta
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Resumo em Inglês
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Infusões Intra-Arteriais
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Protocolos de Quimioterapia Combinada Antineoplásica
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Cisplatino
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Carcinoma Hepatocelular
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Trombose Venosa
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Artéria Hepática
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Neoplasias Hepáticas
Tipo de estudo:
Guideline
Limite:
Adult
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Female
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Humans
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Male
Idioma:
Ko
Revista:
The Korean Journal of Hepatology
Ano de publicação:
2005
Tipo de documento:
Article