Early Experiences with Nivolumab in Patients with Metastatic Renal Cell Carcinoma and Failed Target Therapy
Korean Journal of Urological Oncology
; : 96-102, 2019.
Article
em En
| WPRIM
| ID: wpr-760332
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE:
The efficacy of nivolumab in metastatic renal cell carcinoma (mRCC) has been proven. However, the nivolumab experience in Korean patients with mRCC is still poorly reported. We report initial experiences with the efficacy and safety of nivolumab in patients with mRCC. MATERIALS ANDMETHODS:
We retrospectively reviewed records for 25 patients with mRCC who had failed targeted therapy and were treated by nivolumab (2 mg/kg, every 2 weeks) at a single institution. The primary endpoint was objective response rate (ORR), and secondary endpoints were progression-free survival (PFS), safety profiles, and ORR in a programmed cell death receptor ligand 1 (PD-L1) expression subgroup.RESULTS:
The median age was 60 years and 16 patients (64%) were male. Objective responses were achieved in 8 patients (32.0%) (complete response, 1; partial response, 7). Median PFS was 3.0 months (95% confidence interval, 1.46–4.53). Treatment-related adverse events (AEs) of any grade were observed in 19 patients (76.0%) with 6 (24.0%) experiencing grade 3 to 4 treatment-related AEs. In subgroups by PD-L1 expression levels classified as 1% or greater and less than 1%, ORR was 50% and 0%, respectively.CONCLUSIONS:
This study showed the efficacy and safety of initial experiences with nivolumab in Korean patients with mRCC who had failed targeted therapy. Our results were comparable to recent clinical trials on nivolumab in mRCC.Palavras-chave
Texto completo:
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Índice:
WPRIM
Assunto principal:
Carcinoma de Células Renais
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Estudos Retrospectivos
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Resultado do Tratamento
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Morte Celular
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Intervalo Livre de Doença
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Antígeno B7-H1
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Metástase Neoplásica
Tipo de estudo:
Observational_studies
Limite:
Humans
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Male
Idioma:
En
Revista:
Korean Journal of Urological Oncology
Ano de publicação:
2019
Tipo de documento:
Article