MRI Assessment of Cerebral Small Vessel Disease in Patients with Spontaneous Intracerebral Hemorrhage
Yonsei Medical Journal
; : 774-781, 2019.
Article
em En
| WPRIM
| ID: wpr-762107
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE:
Cerebral small vessel disease (SVD) is known to be associated with ischemic stroke, intracerebral hemorrhage (ICH), and cognitive impairment. In this retrospective observational study, we explored SVD markers on MRI relevant to spontaneous ICH. MATERIALS ANDMETHODS:
The ICH group consisted of 150 consecutive patients with a first primary parenchymal ICH, and the control group consisted of 271 age- and sex-matched individuals who underwent brain MRI in a health care center. We compared cerebral microbleeds (CMBs), white matter hyperintensities (WMHs), enlarged perivascular space (EPVS), and lacunae in the ICH and control groups.RESULTS:
A total of 1278 CMB lesions were identified in 121 of the 150 patients in the ICH group (80.6%), while 77 CMB lesions were found in 32 of the 271 individuals in the control group (11.8%). WMH and EPVS were more severe and lacunae were more frequent in the ICH patients than in the control group. When receiver operating characteristic (ROC) curves were plotted, number of CMBs most significantly predicted ICH. All imaging markers were significantly associated with ICH in every age group. The location of CMBs coincided with the location of ICH, and ICH volume correlated with CMB count.CONCLUSION:
All MRI markers for SVD were worse in ICH patients than in healthy controls, and these markers were prominent even in young ICH patients. Lacunae, WMH, EPVS, and CMB should be considered as factors related with spontaneous ICH.Palavras-chave
Texto completo:
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Índice:
WPRIM
Assunto principal:
Encéfalo
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Imageamento por Ressonância Magnética
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Hemorragia Cerebral
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Estudos Retrospectivos
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Curva ROC
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Angiopatia Amiloide Cerebral
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Transtornos Cognitivos
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Acidente Vascular Cerebral
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Hemorragias Intracranianas
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Atenção à Saúde
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Yonsei Medical Journal
Ano de publicação:
2019
Tipo de documento:
Article