Factors Related to Blood Intact Incretin Levels in Patients with Type 2 Diabetes Mellitus
Diabetes & Metabolism Journal
; : 495-503, 2019.
Article
em En
| WPRIM
| ID: wpr-763661
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND:
We performed this study to identify factors related to intact incretin levels in patients with type 2 diabetes mellitus (T2DM).METHODS:
We cross-sectionally analyzed 336 patients with T2DM. Intact glucagon-like peptide 1 (iGLP-1) and intact glucose-dependent insulinotropic polypeptide (iGIP) levels were measured in a fasted state and 30 minutes after ingestion of a standard mixed meal. The differences between 30 and 0 minute iGLP-1 and iGIP levels were indicated as ΔiGLP-1 and ΔiGIP.RESULTS:
In simple correlation analyses, fasting iGLP-1 was positively correlated with glucose, C-peptide, creatinine, and triglyceride levels, and negatively correlated with estimated glomerular filtration rate. ΔiGLP-1 was positively correlated only with ΔC-peptide levels. Fasting iGIP showed positive correlations with glycosylated hemoglobin (HbA1c) and fasting glucose levels, and negative correlations with ΔC-peptide levels. ΔiGIP was negatively correlated with diabetes duration and HbA1c levels, and positively correlated with Δglucose and ΔC-peptide levels. In multivariate analyses adjusting for age, sex, and covariates, fasting iGLP-1 levels were significantly related to fasting glucose levels, ΔiGLP-1 levels were positively related to ΔC-peptide levels, fasting iGIP levels were related to fasting C-peptide levels, and ΔiGIP levels were positively related to ΔC-peptide and Δglucose levels.CONCLUSION:
Taken together, intact incretin levels are primarily related to C-peptide and glucose levels. This result suggests that glycemia and insulin secretion are the main factors associated with intact incretin levels in T2DM patients.Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Triglicerídeos
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Peptídeo C
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Hemoglobinas Glicadas
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Polipeptídeo Inibidor Gástrico
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Análise Multivariada
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Jejum
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Creatinina
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Diabetes Mellitus Tipo 2
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Ingestão de Alimentos
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Peptídeo 1 Semelhante ao Glucagon
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Diabetes & Metabolism Journal
Ano de publicação:
2019
Tipo de documento:
Article