Familial Pancreatic Cancer and Surveillance of High-Risk Individuals
Gut and Liver
; : 498-505, 2019.
Article
em En
| WPRIM
| ID: wpr-763877
Biblioteca responsável:
WPRO
ABSTRACT
Family history of pancreatic cancer (PC) is a risk factor for PC development, and the risk level correlates with the number of affected families. A case of PC with ≥1 PC cases in the first-degree relative is broadly defined as familial pancreatic cancer (FPC) and accounts for 5% to 10% of total PC cases. FPC possesses several epidemiological, genetic and clinicopathological aspects that are distinct from those of conventional PCs. In Western countries, FPC registries have been established since the 1990s, and high-risk individuals are screened to detect early PCs. For the pharmacotherapy of FPC, especially in cases with germline pathogenic BRCA mutations, regimens using platinum and poly (ADP-ribose) polymerase inhibitor have recently been studied for their effectiveness. To date, the concept of FPC has prevailed in Western countries, and it has begun to infiltrate into Eastern countries. As the genetic background and environmental conditions vary in association with ethnicity and living area, we need to establish our own FPC registries and accumulate data in Asian countries.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Neoplasias Pancreáticas
/
Platina
/
Sistema de Registros
/
Fatores de Risco
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Povo Asiático
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Tratamento Farmacológico
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Patrimônio Genético
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
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Screening_studies
Limite:
Humans
Idioma:
En
Revista:
Gut and Liver
Ano de publicação:
2019
Tipo de documento:
Article