Curcumin Elevates T(FH) Cells and Germinal Center B Cell Response for Antibody Production in Mice
Immune Network
; : e35-2019.
Article
em En
| WPRIM
| ID: wpr-764025
Biblioteca responsável:
WPRO
ABSTRACT
Curcumin is a natural product extracted from Curcuma longa. It has been reported as a potent antioxidant and anti-inflammatory compound. Previous studies have demonstrated that curcumin suppresses pro-inflammatory cytokine production via inhibition of NF-κB in macrophages. However, its role in adaptive immune cells such as T cells, in vivo, has not clearly been elucidated. Here, we examined the effects of curcumin in T follicular helper (T(FH)) cells and on Ab production during NP-ovalbumin immunization in mice. The results revealed that curcumin administered daily significantly increased CXCR5⁺B-cell lymphoma 6⁺ T(FH) cells and CD95⁺GL-7⁺ germinal center (GC) B cells in draining lymph nodes. In addition, curcumin treatment in mice induced total Ab production as well as high affinity IgG1 and IgG2b Ab production. Collectively, these results suggest that curcumin has positive regulatory roles in T(FH) cell functions and GC responses. Thus, this could be an advantageous supplement to enhance humoral immunity against infectious diseases and cancer.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Imunoglobulina G
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Imunoglobulinas
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Linfócitos B
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Linfócitos T
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Doenças Transmissíveis
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Imunização
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Centro Germinativo
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Curcumina
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Curcuma
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Imunidade Humoral
Limite:
Animals
Idioma:
En
Revista:
Immune Network
Ano de publicação:
2019
Tipo de documento:
Article