The Genomic Landscape and Its Clinical Implications in Hepatocellular Carcinoma
Journal of Liver Cancer
; : 97-107, 2019.
Article
em En
| WPRIM
| ID: wpr-765720
Biblioteca responsável:
WPRO
ABSTRACT
The pathogenesis of hepatocellular carcinoma (HCC) is a complex process. During the last decade, advances in genomic technologies enabled delineation of the genomic landscape of HCC, resulting in the identification of the common underlying molecular alterations. The tumor microenvironment, regulated by inflammatory cells, including cancer cells, stromal tissues, and the surrounding extracellular matrix, has been extensively studied using molecular data. The integration of molecular, immunological, histopathological, and clinical findings has provided clues to uncover predictive biomarkers to enhance responses to novel therapies. Herein, we provide an overview of the current HCC genomic landscape, previously identified gene signatures that are used routinely to predict prognosis, and an immune-specific class of HCC. Since biomarker-driven treatment is still an unmet need in HCC management, translation of these discoveries into clinical practice will lead to personalized therapies and improve patient care, especially in the era of targeted and immunotherapies.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Pseudocisto Pancreático
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Pancreatite
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Prognóstico
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Biomarcadores
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Células Estromais
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Carcinoma Hepatocelular
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Matriz Extracelular
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Microambiente Tumoral
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Assistência ao Paciente
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Imunoterapia
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Journal of Liver Cancer
Ano de publicação:
2019
Tipo de documento:
Article