Challenges of NK cell-based immunotherapy in the new era / 医学前沿
Frontiers of Medicine
; (4): 440-450, 2018.
Article
em En
| WPRIM
| ID: wpr-771299
Biblioteca responsável:
WPRO
ABSTRACT
Natural killer cells (NKs) have a great potential for cancer immunotherapy because they can rapidly and directly kill transformed cells in the absence of antigen presensitization. Various cellular sources, including peripheral blood mononuclear cells (PBMCs), stem cells, and NK cell lines, have been used for producing NK cells. In particular, NK cells that expanded from allogeneic PBMCs exhibit better efficacy than those that did not. However, considering the safety, activities, and reliability of the cell products, researchers must develop an optimal protocol for producing NK cells from PBMCs in the manufacture setting and clinical therapeutic regimen. In this review, the challenges on NK cell-based therapeutic approaches and clinical outcomes are discussed.
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Texto completo:
1
Índice:
WPRIM
Assunto principal:
Patologia
/
Terapêutica
/
Células Matadoras Naturais
/
Resultado do Tratamento
/
Alergia e Imunologia
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Imunoterapia
/
Métodos
/
Neoplasias
Tipo de estudo:
Guideline
Limite:
Humans
Idioma:
En
Revista:
Frontiers of Medicine
Ano de publicação:
2018
Tipo de documento:
Article