Progress in gene knockout mice / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 784-794, 2019.
Artigo
em Chinês
| WPRIM
| ID: wpr-771331
ABSTRACT
The establishment and development of gene knockout mice have provided powerful support for the study of gene function and the treatment of human diseases. Gene targeting and gene trap are two techniques for generating gene knockout mice from embryonic stem cells. Gene targeting replaces endogenous knockout gene by homologous recombination. There are two ways to knock out target genes promoter trap and polyA trap. In recent years, many new gene knockout techniques have been developed, including Cre/loxP system, CRISP/Cas9 system, latest ZFN technology and TALEN technology. This article focuses on the several new knockout mouse techniques.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Camundongos Knockout
/
Marcação de Genes
/
Modelos Animais de Doenças
/
Células-Tronco Embrionárias
/
Técnicas de Inativação de Genes
/
Recombinação Homóloga
Limite:
Animais
/
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Biotechnology
Ano de publicação:
2019
Tipo de documento:
Artigo
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