Chemical constituents from root barks of Dictamnus dasycarpus and their cytotoxic activities / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 4869-4877, 2018.
Article
em Zh
| WPRIM
| ID: wpr-771558
Biblioteca responsável:
WPRO
ABSTRACT
Nineteen compounds, including kihadanin D (1), obacunone (2), kihadanin A (3), kihadanin B (4), kihadanin C (5), limonin (6), evodol (7), fraxinellone (8), furo[2,3-b]quinolin-4-ol (9), preskimmianine (10), ifflaiamine (11), dictamnol (12), naringenin (13), diosmetin (14), wogonin (15), scopoletin (16), cleomiscosin A (17), apocynin (18), and methyl pyroglutamate (19), were isolated from the methanol extract of the root barks of Dictamnus dasycarpus by using various column chromatographies. Their chemical structures were extensively determined on basis of UV, IR, NMR, MS, and CD spectroscopic data analyses. Among them, 1 is a new limonoid, 9 was isolated from plant kingdom for the first time, 11, 13-14 and 17-19 were obtained from the genus Dictamnnus for the first time. Cytotoxicities of compounds 1-18 were tested, and the results indicated that 1 exhibited cytotoxicities against three human cancer cell lines MDA-MB-231, A549 and HT29 with IC₅₈ values of 16.22, 21.72 and 31.06 μmol·L⁻¹, respectively.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Extratos Vegetais
/
Estrutura Molecular
/
Raízes de Plantas
/
Casca de Planta
/
Dictamnus
/
Linhagem Celular Tumoral
Limite:
Humans
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2018
Tipo de documento:
Article