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In vitro multi-enzyme molecular machines - a review / 生物工程学报
Chinese Journal of Biotechnology ; (12): 1870-1888, 2019.
Artigo em Chinês | WPRIM | ID: wpr-771746
ABSTRACT
In vitro multi-enzyme molecular machines that follow the designed multi-enzyme pathways, require the rational optimization and adaptation of several purified or partially purified enzyme components, in order to convert certain substrates into target compounds in vitro in an efficient manner. This type of molecular machine is component-based and modularized, so that its design, assembly, and regulation processes are highly flexible. Recently, the advantages of in vitro multi-enzyme molecular machines on the precise control of reaction process and the enhancement of product yield have suggested their great application potential in biomanufacturing. Studies on in vitro multi-enzyme molecular machines have become an important branch of synthetic biology, and are gaining increasing attentions. This article systematically reviews the enzyme component-/module-based construction strategy of in vitro multi-enzyme molecular machines, as well as the research progress on the improvement of compatibility among enzyme components/modules. The current challenges and future prospects of in vitro multi-enzyme molecular machines are also discussed.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Biotecnologia / Química / Enzimas / Biologia Sintética / Metabolismo / Complexos Multienzimáticos Idioma: Chinês Revista: Chinese Journal of Biotechnology Ano de publicação: 2019 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Biotecnologia / Química / Enzimas / Biologia Sintética / Metabolismo / Complexos Multienzimáticos Idioma: Chinês Revista: Chinese Journal of Biotechnology Ano de publicação: 2019 Tipo de documento: Artigo