Genome editing for the treatment of tumorigenic viral infections and virus-related carcinomas / 医学前沿
Frontiers of Medicine
; (4): 497-508, 2018.
Article
em En
| WPRIM
| ID: wpr-772710
Biblioteca responsável:
WPRO
ABSTRACT
Viral infections cause at least 10%-15% of all human carcinomas. Over the last century, the elucidation of viral oncogenic roles in many cancer types has provided fundamental knowledge on carcinogenetic mechanisms and established a basis for the early intervention of virus-related cancers. Meanwhile, rapidly evolving genome-editing techniques targeting viral DNA/RNA have emerged as novel therapeutic strategies for treating virus-related carcinogenesis and have begun showing promising results. This review discusses the recent advances of genome-editing tools for treating tumorigenic viruses and their corresponding cancers, the challenges that must be overcome before clinically applying such genome-editing technologies, and more importantly, the potential solutions to these challenges.
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Texto completo:
1
Índice:
WPRIM
Assunto principal:
Antivirais
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Terapêutica
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Infecções Tumorais por Vírus
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Virologia
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Carcinoma
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Terapia Genética
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Predisposição Genética para Doença
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Usos Terapêuticos
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Sistemas CRISPR-Cas
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Edição de Genes
Limite:
Humans
Idioma:
En
Revista:
Frontiers of Medicine
Ano de publicação:
2018
Tipo de documento:
Article