Antibacterial sorbicillin and diketopiperazines from the endogenous fungus Penicillium sp. GD6 associated Chinese mangrove Bruguiera gymnorrhiza / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 358-365, 2018.
Article
em En
| WPRIM
| ID: wpr-773605
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ABSTRACT
One new sorbicillin derivative, 2-deoxy-sohirnone C (1), one new diketopiperazine alkaloid, 5S-hydroxynorvaline-S-Ile (2), and two naturally occurring diketopiperazines, 3S-hydroxylcyclo(S-Pro-S-Phe) (3) and cyclo(S-Phe-S-Gln) (4), together with three known compounds were isolated from the Chinese mangrove endophytic fungus Penicillium sp. GD6. Their structures were determined on the basis of extensive spectroscopic analyses and by comparison with literature data. The absolute configuration of 3-hydroxyl moiety in 3 was determined by Mosher's method, while the absolute stereochemistry of 2 and 4 was established by comparison with the CD spectra of natural and synthesized diketopiperazines. Compound 1 showed moderate antibacterial activity against Methicillin-resistant Staphylococcus aureus with a MIC value of 80 μg·mL.
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Assunto principal:
Penicillium
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Farmacologia
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Resorcinóis
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Estrutura Molecular
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Testes de Sensibilidade Microbiana
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Química
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China
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Dicroísmo Circular
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Ressonância Magnética Nuclear Biomolecular
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Rhizophoraceae
País/Região como assunto:
Asia
Idioma:
En
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Ano de publicação:
2018
Tipo de documento:
Article