Gait Assessment of Pain and Analgesics: Comparison of the DigiGait™ and CatWalk™ Gait Imaging Systems / 神经科学通报·英文版
Neuroscience Bulletin
; (6): 401-418, 2019.
Article
em En
| WPRIM
| ID: wpr-775430
Biblioteca responsável:
WPRO
ABSTRACT
Investigation of pain requires measurements of nociceptive sensitivity and other pain-related behaviors. Recent studies have indicated the superiority of gait analysis over traditional evaluations (e.g., skin sensitivity and sciatic function index [SFI]) in detecting subtle improvements and deteriorations in animal models. Here, pain-related gait parameters, whose criteria include (1) alteration in pain models, (2) correlation with nociceptive threshold, and (3) normalization by analgesics, were identified in representative models of neuropathic pain (spared nerve injury: coordination data) and inflammatory pain (intraplantar complete Freund's adjuvant: both coordination and intensity data) in the DigiGait™ and CatWalk™ systems. DigiGait™ had advantages in fixed speed (controlled by treadmill) and dynamic SFI, while CatWalk™ excelled in intrinsic velocity, intensity data, and high-quality 3D images. Insights into the applicability of each system may provide guidance for selecting the appropriate gait imaging system for different animal models and optimization for future pain research.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Dor
/
Processamento de Imagem Assistida por Computador
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Adjuvante de Freund
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Ratos Sprague-Dawley
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Análise da Marcha
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Marcha
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Analgésicos
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Inflamação
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Métodos
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Neuralgia
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Neuroscience Bulletin
Ano de publicação:
2019
Tipo de documento:
Article