Taurine Transporter dEAAT2 is Required for Auditory Transduction in Drosophila / 神经科学通报·英文版
Neuroscience Bulletin
; (6): 939-950, 2018.
Article
em En
| WPRIM
| ID: wpr-775496
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WPRO
ABSTRACT
Drosophila dEAAT2, a member of the excitatory amino-acid transporter (EAAT) family, has been described as mediating the high-affinity transport of taurine, which is a free amino-acid abundant in both insects and mammals. However, the role of taurine and its transporter in hearing is not clear. Here, we report that dEAAT2 is required for the larval startle response to sound stimuli. dEAAT2 was found to be enriched in the distal region of chordotonal neurons where sound transduction occurs. The Ca imaging and electrophysiological results showed that disrupted dEAAT2 expression significantly reduced the response of chordotonal neurons to sound. More importantly, expressing dEAAT2 in the chordotonal neurons rescued these mutant phenotypes. Taken together, these findings indicate a critical role for Drosophila dEAAT2 in sound transduction by chordotonal neurons.
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Assunto principal:
Fisiologia
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Vias Auditivas
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Estimulação Acústica
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Potenciais de Ação
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Animais Geneticamente Modificados
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Cálcio
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Biologia Celular
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Transportador 2 de Aminoácido Excitatório
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Proteínas de Drosophila
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Drosophila
Limite:
Animals
Idioma:
En
Revista:
Neuroscience Bulletin
Ano de publicação:
2018
Tipo de documento:
Article