Spinal Cord Stimulation Frequency Influences the Hemodynamic Response in Patients with Disorders of Consciousness / 神经科学通报·英文版
Neuroscience Bulletin
; (6): 659-667, 2018.
Article
em En
| WPRIM
| ID: wpr-775506
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WPRO
ABSTRACT
Spinal cord stimulation (SCS) is a promising technique for treating disorders of consciousness (DOCs). However, differences in the spatio-temporal responsiveness of the brain under varied SCS parameters remain unclear. In this pilot study, functional near-infrared spectroscopy was used to measure the hemodynamic responses of 10 DOC patients to different SCS frequencies (5 Hz, 10 Hz, 50 Hz, 70 Hz, and 100 Hz). In the prefrontal cortex, a key area in consciousness circuits, we found significantly increased hemodynamic responses at 70 Hz and 100 Hz, and significantly different hemodynamic responses between 50 Hz and 70 Hz/100 Hz. In addition, the functional connectivity between prefrontal and occipital areas was significantly improved with SCS at 70 Hz. These results demonstrated that SCS modulates the hemodynamic responses and long-range connectivity in a frequency-specific manner (with 70 Hz apparently better), perhaps by improving the cerebral blood volume and information transmission through the reticular formation-thalamus-cortex pathway.
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Assunto principal:
Fisiologia
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Medula Espinal
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Cirurgia Geral
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Terapêutica
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Encéfalo
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Projetos Piloto
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Estado de Consciência
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Transtornos da Consciência
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Estimulação da Medula Espinal
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Hemodinâmica
Limite:
Adolescent
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Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
Neuroscience Bulletin
Ano de publicação:
2018
Tipo de documento:
Article