Research Advances on Combination Strategies of Demethylating Agents for Elderly Acute Myeloid Leukemia--Review / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 1339-1343, 2019.
Article
em Zh
| WPRIM
| ID: wpr-775717
Biblioteca responsável:
WPRO
ABSTRACT
Abstract Demethylating agents (HMAs) hold an important status in therapy for elderly acute myeloid leukemia, who are not eligible for intensive chemotherapy (ICT). Beyond the edge of monotherapy, domestic and foreign scholars have carried out a lot of studies on combination strategies, such as HMAs with low-intensity therapy (G-CSF, low-dose cytarabine and aclarubicin, CAG), with targeted therapy (BCL-2 inhibitor), with immunotherapy (immune checkpoint inhibitors, ICI), and with other epigenetic therapys (isocitrate dehydrogenase or histonedeacetylase inhibitor). Some of these researches have obtained positive results and discussed the mechanisms of combination strategies besides. In this review, the combination of HMAs with other drugs are summraized briefly.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Aclarubicina
/
Leucemia Mieloide Aguda
/
Protocolos de Quimioterapia Combinada Antineoplásica
/
Fator Estimulador de Colônias de Granulócitos
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Citarabina
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Isocitrato Desidrogenase
Limite:
Aged
/
Humans
Idioma:
Zh
Revista:
Journal of Experimental Hematology
Ano de publicação:
2019
Tipo de documento:
Article