Two new ursane-type nortriterpenes from Lonicera macranthoides and their iNOS-inhibitory activities / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 27-32, 2019.
Article
em En
| WPRIM
| ID: wpr-776908
Biblioteca responsável:
WPRO
ABSTRACT
The flower buds of Lonicera macranthoides (Shan Yin-Hua), represent an important traditional Chinese medicine and food ingredient. A phytochemical investigation of the 70% EtOH extract of the flower buds of L. macranthoides resulted in the isolation of 12 triterpenoids (1-12), including two new ursane-type nortriterpenes, 2α, 24-dihydroxy-23-nor-ursolic acid (1) and 2α, 4α-dihydroxy-23-nor-ursolic acid (2). Their structures were established by multiple spectroscopic methods and comparison with literature data. All isolated compounds were evaluated for their anti-inflammatory effects in LPS-activated RAW264.7 cells. Compounds 1 and 2 exhibited inhibitory effects on iNOS at the concentration of 30 μmol·L.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Farmacologia
/
Plantas Comestíveis
/
Triterpenos
/
Medicamentos de Ervas Chinesas
/
Extratos Vegetais
/
Estrutura Molecular
/
Química
/
Lonicera
/
Flores
/
Etanol
Limite:
Animals
Idioma:
En
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Ano de publicação:
2019
Tipo de documento:
Article