Dendritic Cell Factor 1-Knockout Results in Visual Deficit Through the GABA System in Mouse Primary Visual Cortex / 神经科学通报·英文版
Neuroscience Bulletin
; (6): 465-475, 2018.
Article
em En
| WPRIM
| ID: wpr-777041
Biblioteca responsável:
WPRO
ABSTRACT
The visual system plays an important role in our daily life. In this study, we found that loss of dendritic cell factor 1 (DCF1) in the primary visual cortex (V1) caused a sight deficit in mice and induced an abnormal increase in glutamic acid decarboxylase 67, an enzyme that catalyzes the decarboxylation of glutamate to gamma aminobutyric acid and CO, particularly in layer 5. In vivo electrophysiological recordings confirmed a decrease in delta, theta, and beta oscillation power in DCF1-knockout mice. This study presents a previously unknown function of DCF1 in V1, suggests an unknown contact between DCF1 and GABA systems, and provides insight into the mechanism and treatment of visual deficits.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Patologia
/
Estimulação Luminosa
/
Transtornos da Visão
/
Córtex Visual
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Regulação da Expressão Gênica
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Proteínas Proto-Oncogênicas c-fos
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Camundongos Knockout
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Usos Terapêuticos
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Ginkgolídeos
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Modelos Animais de Doenças
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Neuroscience Bulletin
Ano de publicação:
2018
Tipo de documento:
Article